Human Beta-crystallin A4, CRYBA4 ELISA Kit

SKU: E6546Hu

Size:96 Tests-1 Kit

Background:Beta-crystallin A4 is a protein that in humans is encoded by the CRYBA4 gene. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, is part of a gene cluster with beta-B1, beta-B2, and beta-B3.

Research_area:Others

Applications:ELISA

Target_protein:CRYBA4

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.08ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Beta-crystallin A4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P53673

MASS(Da):22,374

GeneID:1413

Synonyms:Beta-A4 crystallin;Beta-crystallin A4;CRYBA4;CTRCT23;CYRBA4;MCOPCT4

Gene names:CRYBA4

Standard solution:4800ng/L