Human Baculoviral Iap Repeat-containing Protein 3, BIRC3 ELISA Kit

SKU: E6535Hu

Size:96 Tests-1 Kit

Background:Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

Research_area:Cell Biology

Applications:ELISA

Target_protein:BIRC3

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.94ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Baculoviral Iap Repeat-Containing Protein 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13489

MASS(Da):68,372

GeneID:330

Synonyms:API2;Apoptosis inhibitor 2;Baculoviral IAP repeat-containing protein 3;BIRC 3;BIRC3;Cellular inhibitor of apoptosis 2;C-IAP2;hIAP1;hIAP-1;IAP homolog C;Inhibitor of apoptosis protein 1;RING finger protein 49;RING-type E3 ubiquitin transferase BIRC3;TNFR2-TRAF-signaling complex protein 1

Gene names:BIRC3

Standard solution:4800ng/L