Human Atrial natriuretic peptide-converting enzyme,CORIN ELISA KIT

SKU: E4409hu

Size:96 Tests-1 Kit

Background:Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:21288900, PubMed:20489134, PubMed:21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity). {ECO:0000250|UniProtKB:Q9Z319, ECO:0000269|PubMed:10880574, ECO:0000269|PubMed:20489134, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:21763278, ECO:0000269|PubMed:22437503}.; [Isoform 2]: has weaker endopeptidase activity compared to isoform 1.

Research_area:

Applications:ELISA

Target_protein:CORIN

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.82ng/L

Detection range:1.5-90ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Atrial natriuretic peptide-converting enzyme

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y5Q5

MASS(Da):116486

GeneID:10699

Synonyms:CORIN CRN TMPRSS10

Gene names:CORIN

Standard solution:96ng/L