Human Aryl Hydrocarbon Receptor Nuclear Translocator, ARNT ELISA Kit

SKU: E2501Hu

Size:96 Tests-1 Kit

Background:Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).

Research_area:Neuroscience

Applications:ELISA

Target_protein:ARNT

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.86ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Aryl Hydrocarbon Receptor Nuclear Translocator

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P27540

MASS(Da):86,636

GeneID:405

Synonyms:ARNT;ARNT protein;Aryl hydrocarbon receptor nuclear translocator;bHLHe2;Class E basic helix-loop-helix protein 2;Dioxin receptor, nuclear translocator;HIF1B;HIF1BETA;HIF1-beta;HIF-1beta;HIF-1-beta;Hypoxia-inducible factor 1-beta;TANGO;

Gene names:ARNT

Standard solution:3200ng/L