Human Apelin, AP ELISA Kit

SKU: E2014Hu

Size:96 Tests-1 Kit

Background:Endogenous ligand for the apelin receptor (APLNR) (PubMed: 10525157). Drives internalization of the apelin receptor (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity). (Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection (PubMed: 11090199). Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR (PubMed: 11090199). Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives (PubMed: 11090199).

Research_area:Neuroscience

Applications:ELISA

Target_protein:APLN

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.47ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Apelin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9ULZ1

MASS(Da):8,569

GeneID:8862

Synonyms:Apelin;Apelin-13;Apelin-28;Apelin-31;Apelin-36;APJ endogenous ligand;APLN

Gene names:APLN

Standard solution:1600ng/L