Human Androgen Receptor, AR ELISA Kit

SKU: E0991Hu

Size:96 Tests-1 Kit

Background:Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed: 20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.

Research_area:Others

Applications:ELISA

Target_protein:AR

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.095ng/ml

Detection range:0.2-70ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Androgen Receptor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P10275

MASS(Da):99,188

GeneID:367

Synonyms:Androgen receptor;AR;Dihydrotestosterone receptor;Nuclear receptor subfamily 3 group C member 4

Gene names:AR

Standard solution:80ng/ml