Human Activation-induced cytidine deaminase,AICDA ELISA KIT

SKU: E4899Hu

Size:96 Tests-1 Kit

Background:Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). {ECO:0000269|PubMed:18722174, ECO:0000269|PubMed:21385873, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:21518874, ECO:0000269|PubMed:27716525}.

Research_area:

Applications:ELISA

Target_protein:AICDA

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.13mIU/L

Detection range:0.2-60mIU/L

Sample type:Serum, plasma or other biological fluids

Full product name:Activation-induced cytidine deaminase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9GZX7

MASS(Da):23954

GeneID:57379

Synonyms:AICDA AID

Gene names:AICDA

Standard solution:64mIU/L