Human Activated Leukocyte Cell Adhesion Molecule, ALCAM ELISA Kit

SKU: E0202Hu

Size:96 Tests-1 Kit

Background:Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.

Research_area:Others

Applications:ELISA

Target_protein:ALCAM

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.42ng/L

Detection range:9-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Activated Leukocyte Cell Adhesion Molecule

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13740

MASS(Da):65,102

GeneID:214

Synonyms:Activated leukocyte cell adhesion molecule;ALCAM;CD antigen CD166;CD166;CD166 antigen;MEMD

Gene names:ALCAM

Standard solution:2400ng/L