Human 5-Hydroxytryptamine Receptor 1A, HTR1A ELISA Kit

SKU: E4882Hu

Size:96 Tests-1 Kit

Background:G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Research_area:Others

Applications:ELISA

Target_protein:HTR1A

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.026ng/mL

Detection range:0.05-15ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:5-Hydroxytryptamine Receptor 1A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P08908

MASS(Da):46,107

GeneID:3350

Synonyms:5-HT1A;5-HT-1A;5-hydroxytryptamine receptor 1A;G-21;HTR 1A;HTR1A;Serotonin receptor 1A

Gene names:HTR1A

Standard solution:16ng/mL