Human 25-Hydroxycholesterol 7-alpha-hydroxylase, CYP7B1 ELISA Kit

SKU: E3861Hu

Size:96 Tests-1 Kit

Background:A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis (PubMed: 25201972, PubMed: 10748047). Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver (PubMed: 25201972, PubMed: 10748047). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed: 25201972, PubMed: 10748047).

Research_area:Others

Applications:ELISA

Target_protein:CYP39A1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.027ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:25-Hydroxycholesterol 7-Alpha-Hydroxylase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NYL5

MASS(Da):54,116

GeneID:51302

Synonyms:24-hydroxycholesterol 7-alpha-hydroxylase;CYP39A1;Cytochrome P450 39A1;hCYP39A1;Oxysterol 7-alpha-hydroxylase

Gene names:CYP39A1

Standard solution:12.8ng/ml