HMGCS1 Polyclonal Antibody

SKU: E-AB-16482

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: HMGCS1

Target Synonym: 3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble);3-hydroxy-3-methylglutaryl coenzyme A synthase;cytoplasmic;EC 2.3.3.10;HMCS1;HMG CoA synthase;HMG-CoA synthase;HMGCS;HMGCS1;Hydroxymethylglutaryl CoA synthase;cytoplasmic;Hydroxymethylglutaryl-CoA synthase;MGC90332

Research Areas: Cancer;Cardiovascular;Metabolism;Signal transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q01581

Accession:

Background: HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.

Concentration: 0.6 mg/mL

Immunogen: Synthetic peptide of human HMGCS1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: IHC 1:50-1:200

Calculated MW:

ObservedMW: