HLA-DMB Polyclonal Antibody

SKU: E-AB-52583

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:HLA-DMB

Target Synonym:class II antigen HLA-DM beta chain;class II histocompatibility antigen;Class II histocompatibility antigen M beta chain;D6S221E;DMB;HLA class II histocompatibility antigen DM beta chain;HLA-DM histocompatibility type;beta chain;M beta chain;Major histocompatibility complex class II DM beta;MHC class II antigen DMB;MHC class II antigen HLA DM beta chain;MHC class II HLA DMB;OTTHUMP00000029257;Really interesting new gene 7 protein;RING 7;RING7

Research Areas:Immunology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB;IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P28068

Accession:

Background:HLA-DMB (Major Histocompatibility Complex, Class II, DM Beta) is a Protein Coding gene. Diseases associated with HLA-DMB include Red-Green Color Blindness and Red Color Blindness. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is ENSG00000248993.HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

Concentration:1.38 mg/mL

Immunogen:Fusion protein of human HLA-DMB

Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method:Antigen affinity purification

Dilution:WB 1:500-1:2000;IHC 1:30-1:150

Calculated MW:29 kDa

ObservedMW:Refer to figures