GSK3B (Ab-9) Antibody - Cat. #: CSB-PA120951

SKU: CSB-PA120951

Size :100ul

Clone Number:

Aliases:Glycogen Synthase Kinase 3 Beta antibody; Glycogen synthase kinase-3 beta antibody; GSK 3 beta antibody; GSK-3 beta antibody; GSK3B antibody; GSK3B_HUMAN antibody; GSK3beta isoform antibody; Serine/threonine-protein kinase GSK3B antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P49841

Immunogen:Peptide sequence around aa.7~11 (T-T-S-F-A) derived from Human GSK3b.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

Background:Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Fan G, et al. (2003) J Biol Chem. 278(52): 52432-52436.Barry FA, et al. (2003) FEBS Lett. 553(1-2): 173-178.Welsh, et al. (1996) Trends Cell Biol. 6: 274-279.Srivastava A K, et al. (1998) Mol Cell Biochem. 182: 135-141.Cross D. A, et al. (1995) Nature. 378: 785-789.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:GSK3B

Research Areas:Neuroscience?Cancer?Cardiovascular;Metabolism;Signal transduction?Stem cells