GSK3 beta Monoclonal Antibody

SKU: E-AB-22130

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Monoclonal Antibodies

Abbreviation: GSK3 beta

Target Synonym: Glycogen Synthase Kinase 3 Beta;Glycogen synthase kinase-3 beta;GSK 3 beta;GSK-3 beta;GSK3B;GSK3B;GSK3beta isoform;Serine/threonine-protein kinase GSK3B

Research Areas: Cancer;Cardiovascular;Metabolism;Neuroscience;Signal Transduction;Stem Cells

Conjugation: Unconjugated

Host: Mouse

Species reactivity: Human;Mouse;Rat

Application: WB;IHC-p

Isotype: IgG

Clonality: Monoclonal

Clone NO.: Clone:4C3

UNIProt ID: P49841

Accession:

Background: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.

Concentration: 1 mg/mL

Immunogen: Synthetic Peptide of GSK3β

Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Purification method: Protein A purification

Dilution: WB 1:1000-2000;IHC 1:100-200

Calculated MW:

ObservedMW: 46kDa