Gremlin-2 rabbit pAb

SKU: ES8709

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF;ELISA

Reactivity:Human;Mouse

Dilution:WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000

Immunogen:The antiserum was produced against synthesized peptide derived from the Internal region of human GREM2. AA range:71-120

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):19kD

Human_gene_id:64388

Human_swiss_prot_no:Q9H772

Subcellular_location:Secreted .

Other_name:Gremlin-2 (Cysteine knot superfamily 1, BMP antagonist 2;DAN domain family member 3;Protein related to DAN and cerberus)

Background:This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008],