GRB7 rabbit pAb

SKU: ES8778

Size: 100μL

Source:Rabbit

Applications:IHC;IF;ELISA

Reactivity:Human;Mouse;Rat

Dilution:IHC-p 1:50-200, ELISA 1:10000-20000

Immunogen:Synthetic peptide from human protein at AA range: 30-100

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):

Human_gene_id:2886

Human_swiss_prot_no:Q14451

Subcellular_location:Cytoplasm . Cell junction, focal adhesion . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic granule . Cell projection . Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions. .

Other_name:Growth factor receptor-bound protein 7 (B47;Epidermal growth factor receptor GRB-7;GRB7 adapter protein)

Background:The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011],