GLRX2 Antibody - Cat. #: CSB-PA878876DSR1HU

SKU: CSB-PA878876DSR1HU

Size :50ul

Clone Number:

Aliases:bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2) antibody; bA101E13.1 antibody; CGI133 antibody; Glrx2 antibody; GLRX2_HUMAN antibody; Glutaredoxin-2 antibody; Glutaredoxin-2; mitochondrial antibody; GRX2 antibody; mitochondrial antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9NS18

Immunogen:Recombinant Human Glutaredoxin-2, mitochondrial protein (1-124AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:GLRX2

Research Areas:Cancer; Cell biology; Metabolism; Signal transduction