GCLC Polyclonal Antibody

SKU: E-AB-52359

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:GCLC

Target Synonym:EC 6.3.2.2;Gamma ECS;Gamma glutamylcysteine synthetase;Gamma-ECS;Gamma-glutamylcysteine synthetase;GCL;Gclc;GCS;GCS heavy chain;GLCL;GLCLC;Glutamate cysteine ligase catalytic subunit;Glutamate--cysteine ligase catalytic subunit;GSH1

Research Areas:Cancer;Cell Biology;Metabolism;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P48506

Accession:

Background:Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.

Concentration:0.8 mg/mL

Immunogen:Fusion protein of human GCLC

Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method:Antigen affinity purification

Dilution:WB 1:500-1:2000;IHC 1:25-1:100

Calculated MW:73 kDa

ObservedMW:Refer to figures