GAD2 antibody , Cat. # FNab03291

SKU: FNab03291

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)

Background:This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

Immunogen:glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

Synonyms:GAD65

Observed MW:70 kDa

Uniprot ID:Q05329

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IF, IHC

Recommended dilution:WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100

Gene ID:2572

Research Area:Neuroscience, Metabolism, Epigenetics