GAD2 Antibody - Cat. #: CSB-PA258867

SKU: CSB-PA258867

Size :100ul

Clone Number:

Aliases:Glutamate decarboxylase 2; EC 4.1.1.15; Glutamate decarboxylase 65 kDa isoform; GAD-65; 65 kDa glutamic acid decarboxylase

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q4G154

Immunogen:Synthesized peptide derived from Human GAD1/GAD2.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

JB Travers, Chem Senses, Feb 2007; 32: 129 - 137.
Rita Sulahian, Nucleic Acids Res., Mar 2006; 34: 1351 - 1357.
Andrea Pillai, Development, Jan 2007; 134: 357 - 366.
Dmytro P. Yevtushenko, J. Exp. Bot., Aug 2003; 54: 2001 - 2002.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:GAD2

Research Areas:Others