Fluor® 488 Anti-Mouse CD172a/SIRPα Antibody[P84]

SKU: GBS-F1286L

Size:100Tests

Storage:This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Flow Cytometry Antibodies

Abbreviation:CD172a;SIRPα

Target Synonym:BIT;CD172 antigen-like family member A;P84;PTPNS1;SHPS-1;SIRPα

Research Areas:Cell Adhesion;Cell Biology;Immunology;Signal Transduction

Conjugation:Elab Fluor®488

Host:Rat

Species reactivity:Mouse

Application:FCM

Usage:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Isotype:Rat IgG1, κ

Clonality:Monoclonal

Clone NO.:P84

UNIProt ID:Q64314

Background:CD172a, also known as SIRPα, is a type I transmembrane protein with one V-set Ig-like and two C-set Ig-like domains in the extracellular portion, and two ITIM motifs and a proline-rich region in the cytoplasmic tail. CD172a is expressed by monocytes, macrophages, myeloid cells, and neuronal tissue. The phosphorylation of SIRPα ITIMs induces the recruitment and activation of the tyrosine phosphatases PTPN6 and PTPN11, resulting in the negative regulation of several biological processes. The ligands of CD172a are CD47, SP-A, and SP-D.

Concentration:

Control catalog number:E-AB-F09822L

Immunogen:

Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Purification method:

Dilution:

GeneID:19261