FGR Antibody - Cat. #: CSB-PA824952

SKU: CSB-PA824952

Size :100ul

Clone Number:

Aliases:c fgr antibody; c fgr protooncogene antibody; c src 2 proto oncogene antibody; c src2 antibody; Fgr antibody; FGR_HUMAN antibody; FLJ43153 antibody; Gardner Rasheed feline sarcoma viral (v fgr) antibody; Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog antibody; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog antibody; MGC75096 antibody; p55 c fgr protein antibody; P55 FGR antibody; P55-FGR antibody; p55c fgr antibody; p58-Fgr antibody; p58c fgr antibody; p58c-Fgr antibody; Proto oncogene c Fgr antibody; Proto oncogene tyrosine protein kinase FGR antibody; Proto-oncogene c-Fgr antibody; SRC 2 antibody; SRC2 antibody; Tyrosine protein kinase Fgr antibody; Tyrosine-protein kinase Fgr antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P09769

Immunogen:Synthesized peptide derived from internal of Human FGR.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.

Katamine S., Mol. Cell. Biol. 8:259-266(1988).
Gregory S.G., Nature 441:315-321(2006).
Brickell P.M., Br. J. Cancer 58:704-709(1988).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FGR

Research Areas:Cancer;Signal transduction