FADD Monoclonal Antibody

SKU: BT-MCA2731

Size:100μL

Background:The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

Research_area:Cell Biology

Target_protein:FADD

applications:FCM

Reactivity:

Clonality:Monoclonal

Clone ID:5A6A2

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:FADD

Immunogen:Purified recombinant fragment of human FADD (AA: 20-150) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):23.3kDa

UniProt accession:Q13158

Synonyms:GIG3, MORT1

GeneID:8772