EYA2 Antibody - Cat. #: CSB-PA007907LA01HU

SKU: CSB-PA007907LA01HU

Size :50ug

Clone Number:

Aliases:EAB 1 antibody; EAB1 antibody; EYA 2 antibody; EYA transcriptional coactivator and phosphatase 2 antibody; EYA2 antibody; EYA2_HUMAN antibody; eyes absent 2 homolog (Drosophila) antibody; Eyes absent homolog 2 (Drosophila) antibody; Eyes absent homolog 2 antibody; Translation of this uORF probably lowers the translation efficiency of EYA2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O00167

Immunogen:Recombinant Human Eyes absent homolog 2 protein (1-514AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates \'Tyr-142\' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. \'Tyr-142\' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:EYA2

Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Signal transduction