ESR2 antibody , Cat. # FNab02867

SKU: FNab02867

Size:100ug

Purification:Protein A+G purification

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Mouse

Clonality:monoclonal

Clone ID:0A10

Isotype:IgG1

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements(ERE) in an estrogen-dependent manner(PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

Immunogen:estrogen receptor 2(ER beta)

Synonyms:ER BETA, Erb, ESR BETA, ESR2, ESRB, ESTRB, estrogen receptor 2 (ER beta), Estrogen receptor beta, NR3A2

Observed MW:50 kDa

Uniprot ID:Q92731

Reactivity:Human, Mouse

Tested Application:ELISA, WB

Recommended dilution:WB: 1:500-1:2000

Gene ID:2100

Research Area:Signal Transduction, Metabolism, Immunology, Cancer, Developmental biology, Neuroscience, Cell Division and Proliferation