EPHB4 Antibody - Cat. #: CSB-PA277115

SKU: CSB-PA277115

Size :100ul

Clone Number:

Aliases:Ephb4 antibody; EPHB4_HUMAN antibody; Ephrin receptor EphB4 antibody; Ephrin type-B receptor 4 antibody; Hepatoma Transmembrane Kinase antibody; HTK antibody; MYK 1 antibody; MYK1 antibody; TYRO 11 antibody; TYRO11 antibody; Tyrosine-protein kinase receptor HTK antibody; Tyrosine-protein kinase TYRO11 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P54760

Immunogen:Synthesized peptide derived from internal of Human EPHB4.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.

Bennett B.D., J. Biol. Chem. 269:14211-14218(1994).
Wilson M.D., Nucleic Acids Res. 29:1352-1365(2001).
Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:EPHB4

Research Areas:Neuroscience;Cardiovascular;Stem cells