DFFA Antibody - Cat. #: CSB-PA783338

SKU: CSB-PA783338

Size :50ul

Clone Number:

Aliases:A330085O09Rik antibody; Caspase activated deoxyribonuclease inhibitor short form antibody; DFF 1 antibody; DFF 45 antibody; DFF alpha antibody; DFF-45 antibody; DFF1 antibody; DFF35 antibody; DFF45 antibody; DFFA antibody; Dffa DNA fragmentation factor, alpha subunit antibody; DFFA_HUMAN antibody; DNA fragmentation factor 45 kDa subunit antibody; DNA Fragmentation Factor Alpha Subunit antibody; DNA fragmentation factor subunit alpha antibody; DNA fragmentation factor, 45 kD, alpha subunit antibody; DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1 antibody; DNA fragmentation factor, 45kDa, alpha polypeptide antibody; DNA fragmentation factor, alpha subunit antibody; DNAation factor 45 kDa subunit antibody; H13 antibody; ICAD antibody; ICAD L antibody; ICAD S antibody; Inhibitor of CAD antibody; Inhibitor of Caspase Activated DNase antibody; MGC143066 antibody; OTTHUMP00000001903 antibody; OTTHUMP00000001904 antibody; RP23 121D17.3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O00273

Immunogen:Fusion protein of Human DFFA

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; ELISA:1:1000-1:5000, IHC:1:25-1:100

Background:Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DFFA

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology;Metabolism