DACH1 Antibody - Cat. #: CSB-PA006482LA01HU

SKU: CSB-PA006482LA01HU

Size :50ug

Clone Number:

Aliases:DACH antibody; Dach1 antibody; DACH1_HUMAN antibody; Dachshund family transcription factor 1 antibody; dachshund homolog 1 (Drosophila) antibody; Dachshund homolog 1 antibody; Dachsund homolog 1 antibody; FLJ10138 antibody; OTTHUMP00000018494 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UI36

Immunogen:Recombinant Human Dachshund homolog 1 protein (166-369AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DACH1

Research Areas:Epigenetics and Nuclear Signaling; Cancer