DAB2 Polyclonal Antibody

SKU: E-AB-14925

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: DAB2

Target Synonym: DAB 2;Dab;mitogen-responsive phosphoprotein;homolog 2 (Drosophila);DAB2;Differentially expressed in ovarian cancer 2;Differentially expressed protein 2;Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein);Disabled homolog 2;Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila);Disabled homolog 2 mitogen responsive phosphoprotein;Disabled;Drosophila;homolog of;2;DOC 2;DOC2;FLJ26626;Mitogen responsive phosphoprotein

Research Areas: Cancer;Epigenetics and Nuclear Signaling;Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: WB;IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P98082

Accession:

Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Concentration: 0.6 mg/mL

Immunogen: Recombinant protein of human DAB2

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: WB 1:500-1:2000;IHC 1:50-1:200

Calculated MW: 82kDa

ObservedMW: