CSNK2A2 Monoclonal Antibody

SKU: BT-MCA3570

Size:100μL

Background:Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.

Research_area:Signal transduction

Target_protein:CSNK2A2

applications:WB, FCM

Reactivity:Human, Mouse

Clonality:Monoclonal

Clone ID:1E1

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CSNK2A2

Immunogen:Purified recombinant fragment of human CSNK2A2 (AA: 194-350) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):41.2kDa

UniProt accession:P19784

Synonyms:CK2A2, CSNK2A1, FLJ43934

GeneID:1459