CPEB4 Antibody, Biotin conjugated - Cat. #: CSB-PA618177LD01HU

SKU: CSB-PA618177LD01HU

Size :50ug

Clone Number:

Aliases:CPE binding protein 4 antibody; CPE-binding protein 4 antibody; CPE-BP4 antibody; cpeb4 antibody; CPEB4_HUMAN antibody; Cytoplasmic polyadenylation element binding protein 4 antibody; Cytoplasmic polyadenylation element-binding protein 4 antibody; hCPEB-4 antibody; KIAA1673 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q17RY0

Immunogen:Recombinant Human Cytoplasmic polyadenylation element-binding protein 4 protein (244-515AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5\\\'-UUUUUAU-3\\\') within the mRNA 3\\\'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CPEB4

Research Areas:Epigenetics and Nuclear Signaling