CD182 Monoclonal Antibody

SKU: BT-MCA3796

Size:100μL

Background:The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Research_area:Others

Target_protein:CD182

applications:IHC, ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:5F7A11

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CD182

Immunogen:Purified recombinant fragment of human CD182 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):40.8kDa

UniProt accession:P25025

Synonyms:CXCR2, IL8R2, IL8RA, IL8RB, CMKAR2, CDw128b

GeneID:3579