CD124 Monoclonal Antibody

SKU: BT-MCA3347

Size:100μL

Background:This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.

Research_area:Others

Target_protein:CD124

applications:FCM

Reactivity:

Clonality:Monoclonal

Clone ID:4B12B12

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:CD124

Immunogen:Purified recombinant fragment of human CD124 (AA: 26-232) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):89.7kDa

UniProt accession:P24394

Synonyms:IL4R, IL4RA, IL-4RA

GeneID:3566