CD10 Rabbit pAb

SKU: EA321

Size: 100μL

Source:Rabbit

Applications:IHC

Reactivity:Human, Rat, Mouse

Dilution:IHC 1:200-500

Immunogen:Recombinant Protein

Storage_stability:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Polyclonal

Isotype:IgG

Concentration:1mg/mL

Observed_band(KD):85kDa

Human_gene_id:4311

Human_swiss_prot_no:P08473

Subcellular_location:Cell membrane

Other_name:CALLA, Enkephalinase,MME,NEP, Neutral endopeptidase antibody

Background:CD10 is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid beta.