CCND2 (Ab-280) Antibody - Cat. #: CSB-PA931919

SKU: CSB-PA931919

Size :100ul

Clone Number:

Aliases:CCND 2 antibody; ccnd2 antibody; CCND2_HUMAN antibody; CyclinD2 antibody; G1/S specific cyclin D2 antibody; G1/S-specific cyclin-D2 antibody; KIAK0002 antibody; MGC102758 antibody; MPPH3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P30279

Immunogen:Synthesized non-phosphopeptide derived from Human Cyclin D2 around the phosphorylation site of threonine 280 (A-S-T(p)-P-T).

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.

Xiong Y., Genomics 13:575-584(1992).
Palmero I., Oncogene 8:1049-1054(1993).
Kalnine N., Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CCND2

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology