CCND1 Monoclonal Antibody

SKU: BT-MCA3579

Size:100μL

Background:During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by acting as regulatory subunits of the Cdks. Early in the G1 phase of the cell cycle, cyclin D1 induction is followed by cyclin E induction. This sequential progression is marked early on in G1 by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB. The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2. In a recent study, Cyclin D1 regulates cellular metabolism, fat cell differentiation and cellular migration. Cyclin D1 is also involved in development and cancer. Cyclin D1 has also been linked to the development and progression of several cancers including breast, bladder, esophagus, and lung.

Research_area:Cell Biology

Target_protein:CCND1

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:3D8

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CCND1

Immunogen:Purified recombinant fragment of human CCND1 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):33.7kDa

UniProt accession:P24385

Synonyms:BCL1, PRAD1, U21B31, D11S287E, CCND1

GeneID:595