CBX2 Antibody - Cat. #: CSB-RA632623A0HU

SKU: CSB-RA632623A0HU

Size :50ul

Clone Number:24A2

Aliases:Chromobox protein homolog 2, CBX2

Product Type:Recombinant Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q14781

Immunogen:A synthesized peptide derived from human CBX2

Raised in:

Species Reactivity:Human, Rat

Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:2000

Background:Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780). {ECO:0000250|UniProtKB:P30658, ECO:0000269|PubMed:19361780, ECO:0000269|PubMed:21282530}.

Clonality:Monoclonal

Isotype:Rabbit IgG

Purification Method:Affinity-chromatography

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CBX2

Research Areas:Epigenetics and Nuclear Signaling