CASR Polyclonal Antibody

SKU: E-AB-18582

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: CASR

Target Synonym: Ca sensing receptor;Ca2+ sensing receptor 1;Ca2+ sensing receptor;Calcium sensing receptor;CAR;CaSR;CASR;EIG8;Extracellular calcium sensing receptor;Extracellular calcium sensing receptor [Precursor];Extracellular calcium-sensing receptor;FHH;FIH;GPRC2A;HHC;HHC1;Hypocalciuric hypercalcemia 1;Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism;MGC138441;NSHPT;Parathyroid Ca(2+) sensing receptor 1;Parathyroid Cell calcium sensing receptor;Parathyroid Cell calcium-sensing receptor;PCAR 1;PCaR1

Research Areas: Cancer;Metabolism;Neuroscience;Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P41180

Accession:

Background: CASR (Calcium Sensing Receptor) is a Protein Coding gene. Diseases associated with CASR include Hypocalcemia, Autosomal Dominant and Hyperparathyroidism, Neonatal. Among its related pathways are Proton Pump Inhibitor Pathway, Pharmacodynamics and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and protein kinase binding. An important paralog of this gene is GPRC6A.The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Concentration: 0.5 mg/mL

Immunogen: Fusion protein of human CASR

Buffer: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method: Antigen affinity purification

Dilution: IHC 1:50-1:300

Calculated MW:

ObservedMW: