Caspase 10 (p23/17, Cleaved-Val220) Rabbit pAb

SKU: ES17852

Size: 100μL

Source:Rabbit

Applications:WB; ELISA

Reactivity:Human; Mouse; Rat

Dilution:WB 1:500-2000, ELISA(peptide)1:5000-20000

Immunogen:Synthesized peptide derived from human Caspase 10 (p23/17, Cleaved-Val220)

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):58+23kD

Human_gene_id:843

Human_swiss_prot_no:Q92851

Subcellular_location:cytosol,CD95 death-inducing signaling complex,ripoptosome,

Other_name:Caspase-10 (CASP-10;EC 3.4.22.63;Apoptotic protease Mch-4;FAS-associated death domain protein interleukin-1B-converting enzyme 2;FLICE2;ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]

Background:This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011],