CASP9 Monoclonal Antibody

SKU: BT-MCA4045

Size:100μL

Background:This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Research_area:Cell Biology

Target_protein:CASP9

applications:FCM

Reactivity:

Clonality:Monoclonal

Clone ID:5E8C8

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:CASP9

Immunogen:Purified recombinant fragment of human CASP9 (AA: 331-416) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):46.3kDa

UniProt accession:P55211

Synonyms:MCH6, APAF3, APAF-3, PPP1R56, ICE-LAP6

GeneID:842