Canine Cluster of differentiation 4,CD4 ELISA KIT

SKU: E0118Ca

Size:96 Tests-1 Kit

Background:Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. {ECO:0000250|UniProtKB:P01730}.

Research_area:

Applications:ELISA

Target_protein:CD4

Reactivity:Canine

Assay type:Sandwich

Sensitivity:8.08ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cluster of differentiation 4

Species:Canine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P33705

MASS(Da):51640

GeneID:403931

Synonyms:CD4

Gene names:CD4

Standard solution:3200ng/L