CaMK2 (Phospho-Thr286) Rabbit pAb

SKU: ES17871

Size: 100μL

Source:Rabbit

Applications:WB; ELISA

Reactivity:Human; Mouse; Rat

Dilution:WB 1:500-2000, ELISA(peptide)1:5000-20000

Immunogen:Synthesized pospho peptide derived from human CaMK2 (Phospho-Thr286)

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):54kD

Human_gene_id:817

Human_swiss_prot_no:Q9UQM7/Q13557

Subcellular_location:Cell junction, synapse . Cell junction, synapse, postsynaptic density . Cell projection, dendritic spine . Cell projection, dendrite . Postsynaptic lipid rafts. .

Other_name:Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta;CaMK-II subunit delta;EC 2.7.11.17)

Background:The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008],