CACNA1C Rabbit Polyclonal Antibody

SKU: BT-AP06772

Size:100μL

Background:This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1| alpha-2/delta| beta| and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins| either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits.

Research_area:Cancer; Cardiovascular; Metabolism; Neuroscience; Signal transduction

Target_protein:CACNA1C

applications:WB, ELISA

Reactivity:Human, Rat, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:CACNA1C

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):244310

UniProt accession:Human: Q13936; Mouse: Q01815; Rat: P22002

Synonyms:CACNA1C; Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel; L type; alpha-1 polypeptide; isoform 1; cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2

GeneID:Human: 775; Mouse: 12288; Rat: 24239