C-CBL Monoclonal Antibody

SKU: BT-MCA3666

Size:100μL

Background:The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.

Research_area:Others

Target_protein:C-CBL

applications:WB, IHC, ICC, FCM

Reactivity:Human, Mouse, Rat

Clonality:Monoclonal

Clone ID:3B12

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:C-CBL

Immunogen:Purified recombinant fragment of human C-CBL expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):120kDa

UniProt accession:P22681

Synonyms:CBL, CBL2, NSLL, C-CBL, RNF55

GeneID:867