BRCA1 (Ab-1423) Antibody - Cat. #: CSB-PA186422

SKU: CSB-PA186422

Size :100ul

Clone Number:

Aliases:BRCA 1 antibody; BRCA1 antibody; BRCA1 DNA repair associated antibody; BRCA1/BRCA2 containing complex subunit 1 antibody; BRCA1/BRCA2-containing complex; subunit 1 antibody; BRCA1_HUMAN antibody; BRCAI antibody; BRCC 1 antibody; BRCC1 antibody; Breast and ovarian cancer susceptibility protein 1 antibody; Breast Cancer 1 antibody; Breast Cancer 1 Early Onset antibody; Breast cancer type 1 susceptibility protein antibody; BROVCA1 antibody; FANCS antibody; IRIS antibody; PNCA4 antibody; PPP1R53 antibody; Protein phosphatase 1 regulatory subunit 53 antibody; PSCP antibody; RING finger protein 53 antibody; RNF53 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P38398

Immunogen:Peptide sequence around aa.1421~1425 (H-G-S-Q-P) derived from Human BRCA1.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:200

Background:

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation

Kim ST, et al. (2002) Genes Dev; 16(5): 560-570
Arlt MF, et al. (2004) Mol Cell Biol; 24(15): 6701-6709
Zhang J, et al. (2004) Mol Cell Biol; 24(2): 708-718
Greenberg RA, et al. (2006) Genes Dev; 20(1): 34-46
Tibbetts RS, et al. (2000) Genes Dev; 14(23): 2989-3002

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:BRCA1

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology