Bovine Protein Disulfide-isomerase, P4HB ELISA Kit

SKU: E2246Bo

Size:96 Tests-1 Kit

Background:This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.

Research_area:Others

Applications:ELISA

Target_protein:P4HB

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:0.32ng/mL

Detection range:0.5-200ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Protein Disulfide-Isomerase

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P05307

MASS(Da):57,266

GeneID:281373

Synonyms:Cellular thyroid hormone-binding protein;P4HB;p55;PDI;Prolyl 4-hydroxylase subunit beta;Protein disulfide-isomerase

Gene names:P4HB

Standard solution:240ng/mL