Bovine C-C Motif Chemokine 8, CCL8 ELISA Kit

SKU: E2198Bo

Size:96 Tests-1 Kit

Background:Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene. CCL8 is a small cytokine belonging to the CC chemokine family. The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B, CCR3 and CCR5.

Research_area:Immunology

Applications:ELISA

Target_protein:CCL8

Reactivity:Bovine

Assay type:Sandwich

Sensitivity:7.19ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:C-C motif chemokine 8

Species:Bovine

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q09141

MASS(Da):10,900

GeneID:281044

Synonyms:C-C motif chemokine 8;CCL8;MCP-2;Monocyte chemoattractant protein 2;Monocyte chemotactic protein 2;SCYA8;Small-inducible cytokine A8

Gene names:CCL8

Standard solution:3200ng/L