BCL10 Monoclonal Antibody

SKU: BT-MCA3408

Size:100μL

Background:This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

Research_area:Cell Biology

Target_protein:BCL10

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:3C11F4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:BCL10

Immunogen:Purified recombinant fragment of human BCL10 (AA: 98-234) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):26.3kDa

UniProt accession:O95999

Synonyms:CLAP, mE10, CIPER, IMD37, c-E10, CARMEN

GeneID:8915