ANTXR1 Antibody - Cat. #: CSB-PA276953

SKU: CSB-PA276953

Size :50ul

Clone Number:

Aliases:Anthrax toxin receptor 1 antibody; ANTR1_HUMAN antibody; Antxr1 antibody; ATR antibody; Tumor endothelial marker 8 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9H6X2

Immunogen:Fusion protein of Human ANTXR1

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100

Background:This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ANTXR1

Research Areas:Cardiovascular;Tags & Cell Markers;Microbiology