Anti-NGF Antibody Picoband®

SKU: A00341-3

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: NGF

Specificity:

Background: Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is mapped to 1p13.2. This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.

Immunogen: E.coli-derived human NGF recombinant protein (Position: S122-D186).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Breakefield, X. O., Orloff, G., Castiglione, C., Coussens, L., Axelrod, F. B., Ullrich, A. Structural gene for beta-nerve growth factor not defective in familial dysautonomia. Proc. Nat. Acad. Sci. 81: 4213-4216, 1984. 2. Carrier, A., Rosier, M.-F., Guillemot, F., Goguel, A.-F., Pulcini, F., Bernheim, A., Auffray, C., Devignes, M.-D. Integrated physical, genetic, and genic map covering 3 Mb around the human NGF gene (NGFB) at 1p13. Genomics 31: 80-89, 1996. 3. Carvalho, O. P., Thornton, G. K., Hertecant, J., Houlden, H., Nicholas, A. K., Cox, J. J., Rielly, M., Al-Gazali, L., Woods, C. G. A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy. J. Med. Genet. 48: 131-135, 2011.

Uniprot ID: P01138

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 27 kDa

Calculated Molecular Weight: 26959 MW

Gene ID: 4803

Protein Name: Beta-nerve growth factor

Gene Full Name: nerve growth factor

Synonyms: NGF; NGFB; Beta-nerve growth factor; Beta-NGF